Bryan Johnson made his fortune by building Braintree, a payment processing company that acquired Venmo in 2012. PayPal bought the whole business for $800 million in 2013. Johnson walked away in his mid-thirties with hundreds of millions of dollars and one question that would define the rest of his life: what if humans no longer had to die?

That question is no longer just a thought experiment for him. It is his full-time job.

Bryan Johnson runs Blueprint, a health and longevity company that sells supplements, skincare products, and olive oil.

Johnson is 48 years old and lives by a philosophy he calls “Don’t Di3.” He describes it not just as a personal health goal, but as what he believes will become one of the defining ideologies of the 21st century — alongside democracy, capitalism, and major world religions.

After selling Braintree, he launched a venture fund investing in synthetic biology and precision medicine. He then founded Kernel, a biotech company that builds non-invasive brain activity monitors. Along the way, his focus shifted increasingly toward his own body as a testing ground.

He now runs Blueprint, a health and longevity company that sells supplements, skincare products, and olive oil. In November 2024, Blueprint raised $60 million in funding from Silicon Valley investors and celebrities including Kim Kardashian and Paris Hilton.

He targets two hours of REM sleep and two hours of deep sleep each night.

Johnson’s daily routine is built around the idea that health can be managed like a navigation algorithm — fed with data and optimized continuously.

His day begins at 8:30 p.m. That is when he goes to bed. He targets two hours of REM sleep and two hours of deep sleep each night, waking naturally between 4:30 and 5:00 a.m.without an alarm.

His mornings run for roughly five hours before work begins. He starts with the Blueprint supplement stack — a combination of dozens of pills and several powdered drinks. He then works out for about 90 minutes, mixing strength training, cardio, flexibility, and balance exercises.

After the workout, he spends 20 minutes in a sauna set to 200°F. He places ice on his testicles during this time, which he says is intended to protect fertility markers from heat exposure. He follows that with six minutes of red-light and near-infrared therapy, and then 45 minutes of intermittent hypoxia-hyperoxia training — a process that involves breathing alternating low- and high-oxygen air through a mask.

Throughout the day, he attends medical appointments and meets with his science team to review health data.

He tracks the biological age of individual organs and the quality of his stool.

Some of Johnson’s experiments go well beyond conventional medicine. He has received blood plasma infusions from his own son as part of an experimental therapy based on the idea that younger blood may possess regenerative properties. Most longevity scientists consider this therapy unproven, and there is currently no peer-reviewed evidence supporting its anti-aging effects in humans.

Despite spending millions on cutting-edge therapies, Johnson’s most consistent recommendation costs nothing. After testing nearly every major health intervention available, he says sleep remains the single most powerful tool for recovery, performance, and brain health.

He also claims to be the most measured person in human history, tracking the biological age of individual organs, the quality of his stool, and the frequency of his nighttime erections — all as data points in his health optimization model.

He ranks himself number one on the Rejuvenation Olympics, a public leaderboard he co-created that ranks participants by the speed of their biological aging, based on a specific blood test. The scientific validity of this test as a reliable predictor of aging remains debated among researchers.

Johnson’s work has attracted significant criticism from within the longevity research community. Many scientists say he promotes unproven therapies, overstates the significance of his personal results, and gives serious aging research a misleading public image.

His Blueprint company profits directly from the protocols he publicly shares, selling products tied to his personal regimen. Critics point out that this creates a financial incentive to present results favorably.

Whether his methods are science or spectacle depends on who you ask. What is certain is that Bryan Johnson has made not dying the most serious business of his life.